Malignant Tumors of Salivary Gland Origin

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چکیده

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Malignant salivary gland tumors

Salivary gland neoplasms are a heterogeneous and important group of tumors of the Oral and Maxillofacial Pathology. They comprise from 2 to 3% of all the salivary gland lesions and tumors1,2 because their heterogeneity, since several years, different classifications based in clinical or microscopic criteria had been appeared.3-7 The most recent and most widely used is that proposed by Seifert e...

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MTA1 Expression in Benign and Malignant Salivary gland Tumors

Introduction: Salivary gland tumors (SGTs) are important parts of human neoplasms. The most common SGT is pleomorphic adenoma and the most common malignant SGTs are mucoepidermoid carcinoma and adenoid cystic carcinoma (ACC). Metastasis-associated genes 1 (MTA1), a member of the nucleosome remodeling and histone deacetylation complex, is one newly discovered gene which recruits histone deacetyl...

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Neoangiogenesis in Benign and Malignant Salivary Gland Tumors

Introduction: There are few studies investigating the role of neoangiogenesis in biological behavior of salivary gland tumors. CD105 expression has demonstrated greater accuracy for detecting new vessel formation compared with other pan-endothelial molecules. This study aimed to assess and compare intratumoral Micro-Vessel Density (MVD) through using immunohistochemichal expression of CD105 bio...

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Serum Levels of Cyfra 21 in Patients with Benign and Malignant Salivary Gland Tumors

Introduction: Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors. Materials and Methods: In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with m...

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GSK3β and CREB3 Gene Expression Profiling in Benign and Malignant Salivary Gland Tumors

Background: Salivary gland tumors (SGT) are rare lesions with uncertain histopathology. One of the major signaling pathways that participate in the development of several tumors is protein kinase A. In this pathway, glycogen synthase kinase β (GSK3β) and cAMP responsive element binding protein (CREB3) are two genes which are supposed to be down regulated in most human tumors. The expression lev...

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ژورنال

عنوان ژورنال: Annals of Surgery

سال: 1966

ISSN: 0003-4932

DOI: 10.1097/00000658-196605000-00009